An asymmetric synthesis of L-pyrrolysine.
نویسندگان
چکیده
An efficient asymmetric synthesis of the 22nd amino acid L-pyrrolysine has been accomplished. The key stereogenic centers were installed by an asymmetric conjugate addition reaction. A Staudinger/aza-Wittig cyclization was used to form the acid-sensitive pyrroline ring. Pyrrolysine was synthesized in 13 steps in 20% overall yield.
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ورودعنوان ژورنال:
- Organic letters
دوره 14 6 شماره
صفحات -
تاریخ انتشار 2012